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1例48岁女性因继发性癫痫给予丙戊酸钠400 mg,1次/12 h静脉微泵泵入,同时给予莫西沙星、普罗帕酮、硝苯地平。第3天加用丙戊酸钠200 mg,3次/d口服。应用丙戊酸钠第1～7天患者凝血酶原时间(PT)分别为11.0、12.9、12.9、14.7、18.5、23.3、37.7(此数值为第6天第2次检查结果)、41.5 s,活化部分凝血活酶时间(APTT)分别为30.0、44.7、50.9、43.3、66.8、52.6、65.0(此数值为第6天第2次检查结果)、69.0 s,立即停用丙戊酸钠,其他3种药物继续应用。停药后2 d,PT为12.9 s,APTT为41.2 s。
A 48-year-old female patient was infused with 400 mg sodium valproate for 1 hour / 12 h after epilepsy and received moxifloxacin, propafenone and nifedipine simultaneously. On the 3rd day plus sodium valproate 200 mg, 3 times / d orally. Prothrombin time (PT) in patients with sodium valproate on day 1 to day 7 were 11.0, 12.9, 12.9, 14.7, 18.5, 23.3, 37.7 respectively (this value was the second examination on day 6), 41.5 s, Activated partial thromboplastin time (APTT) were 30.0,44.7,50.9,43.3,66.8,52.6,65.0 (this value is the second examination results on the 6th day), 69.0 s, immediate withdrawal of sodium valproate, other 3 kinds of drugs continue to be applied. Two days after discontinuation, PT was 12.9 s and APTT was 41.2 s.