呼吸道合胞病毒(RSV)中和抗体对易感儿童RSV感染的治疗及预防作用

来源 :解放军医学情报 | 被引量 : 0次 | 上传用户:xiao137wu
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RSV在全球是婴儿和儿童呼吸道最重要的病原体。每年由此导致支气管炎及肺炎的流行。它的命名缘于两种特性:病毒从患下呼吸道感染儿童中获得;细胞组织培养具有形成合胞体的能力。80年代中期,科学家并没有因为过去血清中和抗体对抗RSV的研究结果不理想而裹足不前。用ELISA法测定以lot 100RSV痘接种过的婴儿血清中RSV融合(F)和附着糖蛋白(G)的抗体效价。研究发现,病毒 RSV is the most important respiratory and respiratory pathogens in infants and children worldwide. This leads to the annual epidemics of bronchitis and pneumonia. Its naming is due to two characteristics: the virus is obtained from children with lower respiratory tract infections; and cell tissue culture has the ability to form syncytia. In the mid-1980s, scientists were not able to stay away from the unsatisfactory results of previous studies on serum neutralizing antibodies against RSV. Antibody titers of RSV fusion (F) and attached glycoprotein (G) in infant serum vaccinated with lot 100RSV were determined by ELISA. Study found that the virus
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