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目的探讨人胎蓝斑神经元的发育，为蓝斑脊髓移植挑选适宜胎龄的蓝斑细胞提供形态学基础。方法用Ｎｉｓｓｌ染色法系统地观察了人类４一８ｍｏ胎龄蓝斑神经元的发育。结果人胎４ｍｏ蓝斑神经元已经发现，其数目随胎龄增加逐渐减少；胞体由小到大，细胞形态呈圆形、印圆形、锥形、梭形、多角形。细胞密度，胚胎早期升高，晚期随胎龄增长逐渐下降。蓝斑细胞主要位于蓝斑背侧部。结论人胎蓝斑移植时，用胎龄４ｍｏ的蓝斑作为移植供体较适宜。
Objective To investigate the development of human fetal blue-spotted neurons and provide the morphological basis for the selection of blue-spotted placental cells of blue-spotted spinal cord transplantation. Methods Nissl staining was used to systematically observe the development of human blue locus coeruleus neurons from 4 to 8 months. Results The human fetal 4mo locus coeruleus neurons had been found to decrease gradually with the increase of gestational age. The number of cell bodies varied from small to large with round, round, conical, fusiform and polygonal shapes. Cell density, early embryos increased, late with the gestational age increased gradually decreased. Locus plaque is mainly located in the back of the blue spot. Conclusions In the case of human fetal blue spot transplantation, it is more appropriate to use the blue spot of 4 months gestational age as donor for transplantation.