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目的探讨农村社区原发性高血压患者血清γ-谷氨酰转肽酶(gamma-glutamyltransferase,GGT)与代谢综合征(metabolic syndrome,MS)组分相关性。方法纳入连云港市农村社区45～75岁原发性高血压患者12 879人,进行病史询问、血压测量、体检,并采集静脉血以检测血糖、血脂等生化指标。结果总人群GGT水平中位数为23.0(17.0,34.1)U/L,其中男性29.0(21.0,46.0)U/L;女性20.0(15.0,28.9)U/L。GGT水平升高(≥40 U/L)占总人群18.8%,其中男性占32.6%;女性占10.7%。MS患病率为41.5%(男性:24.0%,女性51.7%)。总人群中GGT水平升高的OR(95%CI)在甘油三酯(triglyceride,TG)水平升高组、空腹血糖(fasting plasma glucose,FPG)升高组及MS患病组分别为2.37(2.16～2.61)、2.01(1.83～2.20)和1.42(1.30～1.56)。多元线性回归显示,GGT水平与FPG(男性:β=0.314 2,P<0.001;女性:β=0.434 9,P<0.001),TG(男性:β=0.369 1,P<0.001;女性:β=0.248 0,P<0.001)密切相关。结论原发性高血压患者血清GGT水平与TG、FPG水平及MS相关。
Objective To investigate the relationship between serum glutamyl transpeptidase (GGT) and metabolic syndrome (MS) in patients with essential hypertension in rural community. Methods A total of 12 879 essential hypertension patients aged 45-75 years old were enrolled in the rural community of Lianyungang City. Their medical history, blood pressure and physical examination were taken and venous blood was collected to detect the biochemical indexes such as blood glucose and blood lipid. Results The median GGT level of the total population was 23.0 (17.0,34.1) U / L, of which 29.0 (21.0,46.0) U / L for males and 20.0 (15.0,28.9) U / L for females. GGT levels (≥40 U / L) accounted for 18.8% of the total population, of which 32.6% of men and 10.7% of women. The prevalence of MS was 41.5% (24.0% in males and 51.7% in females). OR (95% CI) in the general population with elevated GGT levels were significantly higher in the triglyceride (TG) group, the fasting plasma glucose (FPG) group and the MS group as 2.37 (2.16 ~ 2.61), 2.01 (1.83 ~ 2.20) and 1.42 (1.30 ~ 1.56) respectively. Multivariate linear regression showed that GGT levels were positively correlated with FPG (male: β = 0.314 2, P <0.001; women: β = 0.434 9, P <0.001) 0.248 0, P <0.001). Conclusion Serum GGT levels in patients with essential hypertension are related to TG, FPG levels and MS.