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目的探讨左乙拉西坦添加治疗对难治性部分性癫痫患者认知功能的影响。方法选取2013年1月—2015年7月武汉市汉阳医院神经内科收治的难治性部分性癫痫患者60例,随机分为对照组与观察组,各30例。对照组患者均予以卡马西平、丙戊酸钠、苯巴比妥治疗,观察组患者在对照组基础上添加左乙拉西坦治疗。观察两组患者临床疗效、治疗前后认知功能及不良反应发生情况。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者视空间和执行能力、命名、注意、语言、抽象、延迟回忆、定向、蒙特利尔认知评估量表(MOCA)总分比较,差异无统计学意义(P>0.05),治疗后观察组患者注意、延迟记忆、MOCA总分高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论左乙拉西坦添加治疗难治性部分性癫痫的临床疗效显著,可改善患者的认知功能,且不良反应少。
Objective To investigate the effect of levetiracetam on cognitive function in patients with refractory partial epilepsy. Methods Sixty patients with refractory partial epilepsy who were admitted to Department of Neurology, Hanyang Hospital, Wuhan from January 2013 to July 2015 were randomly divided into control group and observation group, with 30 cases in each group. Patients in the control group were treated with carbamazepine, sodium valproate and phenobarbital. Patients in the observation group were treated with levetiracetam on the basis of the control group. The clinical efficacy, cognitive function and adverse reactions in both groups were observed before and after treatment. Results The total effective rate of the observation group was higher than that of the control group (P <0.05). Before treatment, the visual spatial and executive abilities, naming, attention, language, abstraction, delayed recall, orientation, Montreal cognition There was no significant difference in MOCA scores (P> 0.05). The scores of attention, delayed memory and MOCA in observation group were higher than those in control group after treatment (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusions Levetiracetam can improve the cognitive function of patients with refractory partial epilepsy and improve adverse reactions.