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目的 研究一氧化氮 (NO)在院内感染性肺炎 (NP)发病中的免疫机制。方法 以气管切开 (插管 )病人为研究对象 ,应用防污染标本刷 (PSB)技术 ,采用化学比色法测定NP患者血清NO水平。结果 病例组 (NP组 )较对照组血清NO水平显著升高 (P <0 0 1) ,动态观察表明 ,病例组在入院第 5～ 7dNO又呈上升趋势 ,这恰与出现NP的时间相吻合 ,且NO浓度与TNF -α浓度呈显著正相关 (P <0 0 1)。结论 NO在NP免疫炎症反应中具有重要作用 ,深入研究NO与TNF -α等细胞因子的关系将为NP的治疗、预防开辟新的思路。
Objective To study the immune mechanism of nitric oxide (NO) in the pathogenesis of nosocomial pneumonia (NP). Methods Tracheotomy (intubation) patients were selected as research objects. The anti-pollution specimen brush (PSB) technique was used to detect the serum NO level in patients with NP. Results Compared with the control group, the level of serum NO was significantly increased in case group (P <0.01). The dynamic observation showed that there was an upward trend in the case group on the 5th to 7th day after admission, which coincided with the time of emergence of NP , And there was a significant positive correlation between NO concentration and TNF-α concentration (P <0.01). CONCLUSION NO plays an important role in NP immune inflammatory response. Further study on the relationship between NO and TNF-α and other cytokines will be the treatment of NP and prevent the development of new ideas.