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目的探讨血清肿瘤标志物CA72-4、CEA、CA199和CA125对胃癌患者术前评估的价值。方法回顾性分析昆明医科大学第二附属医院胃肠外科2013年6月至2014年6月期间收治的70例胃癌手术患者术前血清肿瘤标志物CA72-4、CEA、CA199及CA125及其临床病理资料。结果血清CA72-4浓度与肿瘤直径、TNM分期、肿瘤浸润深度及淋巴转移数目有关(P<0.05);CA199浓度与肿瘤直径、TNM分期及肿瘤浸润深度有关(P<0.05);CEA和CA125浓度与肿瘤直径、TNM分期及远处转移有关(P<0.05);上述4项指标均与患者年龄和性别无关(P>0.05)。结论血清肿瘤标志物CA72-4、CEA、CA199及CA125对胃癌术前评估具有一定的临床价值。
Objective To investigate the value of serum tumor markers CA72-4, CEA, CA199 and CA125 in preoperative evaluation of gastric cancer patients. Methods The preoperative serum tumor markers CA72-4, CEA, CA199 and CA125 in 70 patients with gastric cancer admitted from June 2013 to June 2014 in Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University were retrospectively analyzed. data. Results Serum concentration of CA72-4 was correlated with tumor diameter, TNM stage, depth of tumor invasion and lymph node metastasis (P <0.05). CA199 concentration was correlated with tumor diameter, TNM stage and tumor invasion depth (P <0.05) Which was related to tumor diameter, TNM stage and distant metastasis (P <0.05). The above four indexes were not related to patient’s age and gender (P> 0.05). Conclusion Serum tumor markers CA72-4, CEA, CA199 and CA125 have certain clinical value in preoperative evaluation of gastric cancer.