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目的:探讨HPV阳性、细胞学检查结果为未明确意义的不典型鳞状上皮细胞(ASCUS)的妇女中,HPV病毒载量用于预测宫颈病变严重程度的价值。方法:收集2012年1月至11月在我院行第2代杂交捕获法(HC2)检测HPV阳性、细胞学诊断为ASCUS,且明确病理诊断的134例妇女作为研究对象。按病毒载量分组:低载量组(1.0≤RLU/CO<10)43例,中载量组(10≤RLU/CO<100)41例,高载量组(RLU/CO>100.00)50例。比较3组妇女的病理结果差异。结果:134例ASCUS妇女中慢性宫颈炎93例(69.4%)、CINⅠ17例(12.7%)、CINⅡ/Ⅲ12例(9.0%)、宫颈癌12例(9.0%)。低载量组中慢性宫颈炎检出率显著高于高载量组(P<0.05),而高级别癌前病变(CINⅡ/Ⅲ)检出率显著低于高载量组(P<0.05),两组宫颈癌检出率无显著差异。中载量组的病理结果与低、高载量组无显著差异。结论:HC2检测HPV阳性、细胞学筛查结果为ASCUS的妇女,HPV病毒载量可用于预测宫颈病变严重程度,具有一定价值。
Objective: To investigate the value of HPV viral load in predicting the severity of cervical lesions in women with HPV-positive and atypical squamous cells (ASCUS) whose cytology results are undefined. Methods: A total of 134 women with HPV positive, cytologic diagnosis ASCUS and clear pathological diagnosis were collected from the second generation hybrid capture (HC2) in our hospital from January to November in 2012. According to the viral load group, 43 cases were in the low-load group (1.0≤RLU / CO <10), 41 in the middle-load group (10≤RLU / CO <100) example. Three groups of women compared the pathological differences. Results: Ninety-three cases (69.4%) of chronic cervicitis in 134 ASCUS women were diagnosed as CINⅠ (12.7%), CINⅡ / Ⅲ (9.0%) and cervical cancer (12%). The detection rate of chronic cervicitis in the low-load group was significantly higher than that in the high-load group (P <0.05), while the detection rate of high-grade precancerous lesions (CINⅡ / Ⅲ) There was no significant difference between the two groups in the detection rate of cervical cancer. There was no significant difference between the medium-dose group and the low- and high-load groups. CONCLUSION: HC2 is a positive test for HPV and cytological screening results are for women with ASCUS. The HPV viral load can be used to predict the severity of cervical lesions and has some value.