糖尿病性肾病系微血管病变的代表疾病,且可明显影响患者预后。为此,闸明本病的发病机理和病变发展过程,乃是当今研究的课题。其中血栓形成在促进微血管病变中起着重要作用。血栓形成的原因推测与血液凝固纤溶系统变化,高脂血症及血小板功能异常有关。研究对象是糖尿病患者136例,男女各68例,年龄24～83岁(平均60岁)。其中饮食疗法73例,口服降糖药23例,胰岛素治疗40例。蛋白尿程度分为Ⅳ级。Ⅰ级(75例):蛋白尿阴性,Ⅱ级(28例):间歇性蛋白尿,Ⅲ级(17例);持续性蛋白尿,每日少于1g。Ⅳ级(16例):,持续性蛋白尿,每日多于1g。测定项目及正常值:纤维蛋白原(Fbg):150～340mg/dl,抗凝血酶Ⅲ(ATⅢ)20～29IU/d1,纤溶酶原(PIg):75～125%,α_1—抗胰蛋白酶(α_1-AT)190～350mg/d1,α_2—臣球蛋白(α_2-MG):120～340mg/d1,α_2—纤溶酶抑制剂(α_2-PI)80～120%,总胆固醇 Diabetic nephropathy is a representative disease of microangiopathy, and can significantly affect the prognosis of patients. To this end, Gakuchi pathogenesis of this disease and pathological development process, but the subject of today’s research. Thrombosis plays an important role in the promotion of microangiopathy. The reason of thrombosis is presumed to be related to changes of blood coagulation and fibrinolysis system, hyperlipidemia and abnormal platelet function. The study object was 136 patients with diabetes mellitus, 68 men and women, aged from 24 to 83 years (average 60 years). Among them, 73 cases of diet therapy, 23 cases of oral hypoglycemic agents, insulin treatment in 40 cases. Proteinuria is divided into four levels. Grade I (75 cases): proteinuria negative, grade Ⅱ (28 cases): intermittent proteinuria, grade Ⅲ (17 cases); persistent proteinuria, less than 1g daily. Ⅳ grade (16 cases) :, persistent proteinuria, more than 1g daily. Measurement items and normal values: fibrinogen (Fbg): 150 ~ 340mg / dl, antithrombin Ⅲ (AT Ⅲ) 20 ~ 29IU / d1, plasminogen (PIg): 75 ~ 125% 190 ~ 350mg / d1 of protease (α_1-AT), 120 ~ 340mg / d1 of α_2-Crohn’s globulin (α_2-MG), 80 ~ 120% of α_2-plasmin inhibitor