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目的 观察低剂量尿激酶静脉溶栓治疗进展性脑梗死的疗效及其安全性。方法 将 72例急性进展性脑梗死患者随机分为治疗组 (36例 )与对照组 (36例 ) ,两组除常规治疗外 ,治疗组加用尿激酶 (UK) 2 0～ 5 0万U静脉滴注 ,连用 5d。并于治疗前和治疗后 5d、90d比较两组神经功能缺缺损程度及生活状态评分。结果 治疗组近期和远期显效率分别为 5 2 78%和 4 7 2 2 % ,均显著高于对照组的 30 5 5 %及 33 33% (P<0 0 5 )。结论 低剂量尿激酶静脉溶栓治疗进展性脑梗死有效且相对安全。
Objective To observe the curative effect and safety of intravenous thrombolysis with low dose of urokinase in patients with progressive cerebral infarction. Methods Seventy-two patients with acute progressive cerebral infarction were randomly divided into treatment group (36 cases) and control group (36 cases). The two groups were treated with urokinase (UK) 20-50 000 U Intravenous drip, once every 5 days. And before treatment and 5d, 90d after treatment, the degree of neurological deficit and life status were compared between the two groups. Results The immediate and long term effective rates of the treatment group were 5278% and 4722%, respectively, which were significantly higher than those of the control group (30.5% vs 33.33%, P <0.05). Conclusion Low-dose urokinase intravenous thrombolysis is effective and relatively safe for patients with progressive cerebral infarction.