The two-stage and two-phase anaerobic process (TSTP) composed of hydrolytic acidification reactor,first-order and second-order external circulation anaerobic reactors (EC) was taken to treat methanolwastewater. Test results show that TSTP process is quick start-up in 51 d, and the maximum VFA of hydrolytic acidification reactor effluent reaches 876 mg/L. Under the condition of volume loading of 6. 56 kgCOD/m~3·d,COD removal rate of the first-order EC reactor is about 85%, and under the condition of volume loading of 1.02 kgCOD/m~3·d, COD removal rate of the second-order EC reactor is about 50%. When the inflow COD of TSTP process is between 7000-11000 mg/L, its effluent COD is lower than 600 mg/L. In the biological conversion process of methanol into methane, the production of acetic acids as an intermediate product can be ignored and the direct production of methane from methanol is predominant.