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目的观察慢性乙肝重型肝炎倾向患者的激素治疗效果,为临床治疗工作提供参考依据。方法选择医院2013年6月-2014年5月收治的慢性乙肝重型肝炎倾向患者76例,随机分为观察组和对照组各38例,对照组采用常规疗法,观察组在对照组基础上加用地塞米松治疗,比较2组的临床治疗效果。结果观察组总有效率为97.4%明显高于对照组的76.3%(P<0.05);治疗后观察组肝功能指标改善较对照组更为显著,差异均有统计学意义(P<0.05);观察组不良反应发生率为18.4%,对照组为5.3%,2组比较差异无统计学意义(P>0.05)。结论慢性乙肝重型肝炎倾向患者的激素治疗效果满意,能够提高疗效,更好地改善肝功能,并且无严重不良反应发生,是可行的药物治疗方案。
Objective To observe the effect of hormone therapy in chronic hepatitis B patients with severe hepatitis, and provide reference for clinical treatment. Methods Seventy-six patients with severe chronic hepatitis B who were admitted to our hospital from June 2013 to May 2014 were randomly divided into observation group (38 cases) and control group (38 cases). The control group was treated with conventional therapy. The observation group Dexamethasone treatment, the clinical treatment of two groups were compared. Results The total effective rate in the observation group was 97.4%, which was significantly higher than that in the control group (76.3%, P <0.05). The improvement of liver function in the observation group was more significant than that in the control group after treatment (P <0.05). The incidence of adverse reactions in the observation group was 18.4% and in the control group was 5.3%. There was no significant difference between the two groups (P> 0.05). Conclusion Hormone therapy in patients with chronic hepatitis B and severe hepatitis is satisfactory, which can improve the curative effect, improve liver function and have no serious adverse reactions. It is a feasible drug regimen.