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目的探讨慢性肾脏病(CKD)患者血清碱性磷酸酶(ALP)与甲状旁腺素(PTH)的相关性,并评估两者在肾性骨病(ROD)诊断及治疗中的意义。方法选择CKD3-5期患者60例,均抽取空腹静脉血,分别测定ALP及PTH,进行相关性分析。结果当PTH>300pg/ml时,ALP与PTH相关性良好,且呈正相关,有统计学意义(r=0.865,P<0.05);当PTH≤300pm/dl时,ALP与PTH无相关性。结论 ALP与PTH相关性良好,随着PTH的增高,ALP增高越明显。两者结合,对诊断和治疗高转运骨病(HTO)有重要的临床价值。且ALP检测方法简单,花费少。
Objective To investigate the correlation between serum alkaline phosphatase (ALP) and parathyroid hormone (PTH) in patients with chronic kidney disease (CKD) and to evaluate their significance in the diagnosis and treatment of renal osteodystrophy (ROD). Methods Sixty patients with stage CKD3-5 were selected. Fasting venous blood was collected and ALP and PTH were measured respectively for correlation analysis. Results When PTH> 300pg / ml, there was a positive correlation between ALP and PTH. There was a positive correlation between ALP and PTH (r = 0.865, P <0.05). Conclusion The correlation between ALP and PTH is good. With the increase of PTH, the increase of ALP is more obvious. The combination of the two has important clinical value in diagnosing and treating HTO. And ALP detection method is simple, less costly.