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目的:通过观察乌司他丁对重症有机磷中毒患者胆碱酯酶活性的安全性。方法:将2013年1月至2014年12月期间到我院急诊科就诊的重症有机磷中毒患者采用随机分为对照组和乌司他丁治疗组。观察胆碱酯酶活性恢复至正常值的50%所用的时间以及需维持阿托品化的时间、平均住院时间、30 d病死率等指标。结果:共有82例患者纳入本研究,实验组和时照组各41例。两组的基线水平无显著统计学差异。治疗组(4.23±0.89)d胆碱酯酶活性恢复至正常值的50%所用的时间比对照组(5.95±1.04)d少((P<0.05)。治疗组住院时间(15.41±4.31)d也比时照组(30.61±10.2)d少;两组需要维持阿托品化的时间和30 d的病死率无明显差别。结论:乌司他丁对重症有机磷中毒患者后期胆碱酯酶的恢复呈现有益的影响,并且可以保护脏器功能,提高对重症有机磷中毒的治疗疗效。
Objective: To observe the safety of ulinastatin in patients with severe organophosphorus poisoning cholinesterase activity. Methods: Patients with severe organophosphate poisoning admitted to our emergency department during January 2013 to December 2014 were randomly divided into control group and ulinastatin group. Observed cholinesterase activity returned to 50% of normal time used and the need to maintain the time of atropine, the average length of stay, 30 d mortality and other indicators. Results: A total of 82 patients were enrolled in this study, 41 cases in each group. There was no significant difference in baseline levels between the two groups. Cholinesterase activity in the treatment group (4.23 ± 0.89) d was reduced to 50% of the normal value (5.95 ± 1.04) d less than that in the control group (P <0.05). The hospitalization time of the treatment group (15.41 ± 4.31) d Also less than the control group (30.61 ± 10.2) d.The time needed to maintain atropine in both groups was not significantly different from that of the control group at 30 days.CONCLUSIONS: Ulinastatin can restore the cholinesterase in patients with severe organophosphate poisoning Showing a beneficial effect, and can protect organ function, improve the treatment of severe organophosphorus poisoning curative effect.