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67Ga-EDTMP was synthesized in a single step by adding 67GaCl3 to EDTMP solution. Dependences of the radiolabeling yield of 67Ga-EDTMP on EDTMP concentration, pH and reaction time were examined. Under the optimum conditions, the radiolabeling yield of 67Ga-EDTMP was more than 97%. A biodistribution experiment in mice showed that 67Ga-EDTMP was mainly absorbed by skeleton and reached 13.25% at 0.5 h after injecting, then kept a high level in 72 h with a maximum value of 16.82% at 48 h. The results suggest that 67Ga-EDTMP might be a potential bone pain palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft-tissue absorption. But further work must be done to determine whether 67Ga-EDTMP is useful in the treatment of painful osseous metastases.
67Ga-EDTMP was synthesized in a single step by adding 67GaCl3 to EDTMP solution. Dependences of the radiolabeling yield of 67Ga-EDTMP on EDTMP concentration, pH and reaction time were examined. Under the optimum conditions, the radiolabeling yield of 67Ga-EDTMP was more than 97%. A biodistribution experiment in mice showed that 67Ga-EDTMP was mainly absorbed by skeleton and reached 13.25% at 0.5 h after injecting, then kept a high level 72 h with a maximum value of 16.82% at 48 h. The results suggests that 67Ga-EDTMP might be a potential bone pain palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft-tissue absorption. Further work must be done to determine whether 67Ga-EDTMP is useful in the treatment of painful osseous metastases.