Detailed experimental and numerical investigations were performed for an ultra-high-lift front-loaded low-pressure turbine cascade (Zw=1.58) with periodic wakes. The interaction mech-anisms between the incoming wakes and endwall secondary flow were carefully examined. Wakes were produced by moving upstream rods, and flow field downstream of the cascade was measured using a seven-hole probe. Experimental results revealed that incoming wakes influenced not only the boundary layer development of the blade suction surface but also the complex endwall secondary vortex structures. On the suction surface:Incoming wakes clearly suppressed the suction side sep-aration bubble at a low Reynolds number of 25000. Nevertheless, the effects of different wake pass-ing frequencies were not significantly different at Re=100000, and the profile losses under wake passing were even greater than in the absence of wakes. At the endwalls: Incoming wakes more strongly suppressed secondary flow at Re=100000 than at Re=25000, because the low-momentum fluid inside the incoming wakes clearly increased the endwall cross-passage pressure gradient at Re=25000. The experimental results indicated that periodic wakes decreased the pas-sage vortex and counter vortex core strength by 25％ and 30％, respectively, at Re=100000. Instantaneous results also demonstrated that endwall secondary vortices decreased significantly near the position of wakes passing.