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目的分析2010年河南省开展麻疹减毒活疫苗(Measles Attenuated Live Vaccine,MV)强化免疫活动(SupplementaryImmunization Activity,SIA)后,疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)的发生特征,探讨MV SIA的安全性。方法采用描述性方法对相关指标进行流行病学分析。结果 2010年河南省MV SIA活动共报告AEFI 872例,发生率4.31/10万剂;男性多于女性。>80%的AEFI出现在接种后<2 d;临床损害以红肿、发热和过敏性皮疹等为主;绝大多数病例预后良好。结论 MV SIA的AEFI监测敏感性高,疫苗安全性良好,接种对象在接种MV后<2 d是监测的重点。
Objective To analyze the incidence of suspected AivelIerative Events Following Immunization (AEFI) after the 2010 Supplementary Immunization Activity (SIA) in Measles Attenuated Live Vaccine (MV) SIA security. Methods The descriptive method was used to carry out epidemiological analysis of related indicators. Results A total of 872 AEFI cases were reported in MV SIA in Henan Province in 2010, with an incidence of 4.31 per 100 000 doses; more men than women. > 80% of AEFI appeared after <2 days of inoculation; the clinical damage mainly consisted of redness, fever and allergic rash; the prognosis was good in the vast majority of cases. Conclusions The AEFI monitoring of MV SIA has high sensitivity and good vaccine safety. The inoculum is less than 2 days after vaccination, which is the focus of monitoring.