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目的:观察使用罗格列酮治疗多囊卵巢综合的治疗效果。方法:收集多囊卵巢综合征患者共60例,随机分为观察组与对照组,各30例,对照组患者使用二甲双孤进行治疗,观察组使用罗格列酮进行治疗,将两组患者的血清睾酮浓度、空腹胰岛素浓度、2 h胰岛素浓度、胰岛素抵抗指数(HOMAIR)进行观察和对比。结果:观察组患者的血清睾酮浓度、空腹胰岛素浓度明显低于对照组,观察组患者2 h胰岛素浓度显著高于对照组,观察组患者的HOMAIR显著低于对照组(P均<0.05)。结论:在多囊卵巢综合征患者的治疗过程中使用罗格列酮进行治疗,能够有效改善患者体内的胰岛素抵抗,调整内分泌的紊乱,并对月经周期进行调节,促进卵泡的发育,值得推广应用。
Objective: To observe the effect of rosiglitazone in the treatment of polycystic ovary syndrome. Methods: A total of 60 patients with polycystic ovary syndrome were randomly divided into observation group and control group, 30 cases in each group. Patients in control group were treated with metformin. Rosiglitazone was used in observation group. Two groups Patients’ serum testosterone concentration, fasting insulin concentration, 2 h insulin concentration, insulin resistance index (HOMAIR) were observed and compared. Results: The serum testosterone concentration and fasting insulin concentration in the observation group were significantly lower than those in the control group. The 2 h insulin concentration in the observation group was significantly higher than that in the control group. The HOMAIR in the observation group was significantly lower than that in the control group (all P <0.05). Conclusion: The treatment of patients with PCOS in the course of treatment with rosiglitazone can effectively improve the patient’s insulin resistance, adjust the endocrine disorders, and regulate the menstrual cycle and promote the development of follicles, it is worth promoting the application .