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目的观察右美托嘧啶对重度颅脑外伤患儿血浆神经烯醇化酶(neuron specific enolase,NSE)的影响。方法 40例ASAⅠ～Ⅱ级的重度颅脑损伤患儿,随机分为对照组(C组)和右美托嘧啶组(D组),观察并记录诱导前T0、手术开始2hT1、术毕T2、术后12hT3时间点血浆NSE含量的变化。结果与C组相比,D组T1-3各时间点血浆NSE的水平组间比较明显降低,差异有统计学意义(P<0.05);与T0时相比,C组T1、2、3时血浆NSE水平逐渐增高,差异均无统计学意义(P>0.05),D组T1、2、3时血浆NSE水平逐渐降低,差异有统计学意义(P<0.05)。结论右美托嘧啶可以降低颅脑损伤患儿围术期血浆NSE水平,可能有脑保护作用。
Objective To observe the effect of dexmedetomidine on plasma neuron enolase (NSE) in children with severe traumatic brain injury. Methods Forty ASA Ⅰ ~ Ⅱ patients with severe traumatic brain injury were randomly divided into control group (C group) and dexmedetomidine group (D group). T0 before induction, 2h T1 after operation, T2, Change of plasma NSE content at 12h after operation. Results Compared with group C, the levels of plasma NSE at T1-3 in group D were significantly lower than those in group C (P <0.05). Compared with group T at T1, Plasma NSE levels gradually increased, the difference was not statistically significant (P> 0.05), plasma NSE levels at T1, 2 and 3 in group D were gradually decreased, the difference was statistically significant (P <0.05). Conclusion Dexmedetomidine can reduce perioperative plasma levels of NSE in children with brain injury and may have neuroprotective effects.