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细胞凋亡调控失调可引起许多临床疾病。Ｂｃｌ－２为一抗凋亡基因，Ｂａｘ能对抗Ｂｃｌ－２的抑制细胞凋亡作用，共同调节细胞凋亡的发生，细胞凋亡能导致前列腺增生和前列腺癌的发生。
Disregulation of apoptosis can cause many clinical diseases. Bcl-2 is an anti-apoptotic gene. Bax can antagonize the apoptosis of Bcl-2 and regulate apoptosis. Apoptosis can lead to benign prostatic hyperplasia and prostate cancer.