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本文以人造沸石(E.Merck)为吸附剂的柱层析和72型分光光度比色法(430nm),用尿累积排泄量来评价国产的一些四环素原料、片剂和糖浆剂在人体内的吸收情况。研究结果表明:四环素原料以A厂的吸收最好,B厂的次之,C厂的较差。片剂以C厂的吸收最好,B厂的次之,A厂的较差。D厂的两种糖浆剂(含六偏磷酸钠和不含六偏磷酸钠)在人体内的吸收,在本实验条件下,所得结果经方差分析无显著差异。A、B、C三厂的原料、片剂及D厂糖浆剂的t_(1/2)在5～6小时,消除速度常数(K)为0.12～0.14,在尿中排泄的原形四环素的排泄率在40～46%之间。
In this paper, artificial column zeolite (E.Merck) as adsorbent column chromatography and 72 spectrophotometric colorimetry (430nm), with urine cumulative excretion to evaluate some of the domestic tetracycline materials, tablets and syrups in the human body Absorption. The results show that: Tetracycline raw materials to plant A best absorption, B plant second, C plant less. The best absorption of tablet C plant, B second, A poor factory. D plant two syrups (including sodium hexametaphosphate and non-sodium hexametaphosphate) absorption in the human body, under the experimental conditions, the results obtained by ANOVA no significant difference. The t_ (1/2) of the raw materials, tablets and D syrup of A, B and C factories were in the range of 5 ~ 6 hours and the elimination rate constants (K) were 0.12 ~ 0.14. The excretion of the prototype tetracycline excreted in the urine Rate of 40 to 46%.