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目的研究二甲双胍对糖尿病前期患者血脂水平的影响。方法将62例糖尿病前期合并高脂血症者分为两组,对照组予饮食及运动治疗指导;观察组在对照组的基础上给予二甲双胍治疗。12周后比较组内和组间治疗前后的空腹血糖及餐后2h血糖、血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白水平的变化。结果对照组空腹及餐后2h血糖水平有下降,但与治疗前比较无统计学意义,血脂水平无明显变化;观察组治疗后血糖及血脂水平均有明显下降,治疗后两组比较,差异有统计学意义。结论二甲双胍可有效降低葡萄糖前期患者空腹及餐后2h血糖、血浆甘油三酯、胆固醇以及低密度脂蛋白水平。
Objective To study the effect of metformin on blood lipid levels in patients with pre-diabetes. Methods Sixty-two pre-diabetic patients with hyperlipidemia were divided into two groups. The control group was given diet and exercise therapy guidance. The observation group was given metformin on the basis of the control group. After 12 weeks, fasting blood glucose and postprandial 2h blood glucose, serum total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein levels were compared between before and after treatment. Results The fasting blood glucose and postprandial blood glucose level decreased at 2h after the treatment, but there was no significant difference between the two groups before treatment. The blood lipid level did not change significantly. The blood glucose and blood lipid levels of the observation group decreased significantly. After treatment, Statistical significance. Conclusion Metformin can effectively reduce the fasting and postprandial blood glucose, plasma triglyceride, cholesterol and low density lipoprotein levels in patients with pre-glucose.