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目的：观察和对比对消化性溃疡所致上消化道出血患者分别采用质子泵抑制剂妥洛克与洛赛克进行治疗的临床效果和不良反应发生情况。方法：本组收集我院2013年7月～2015年6月间接诊的80例消化性溃疡所致的上消化道出血患者进行临床研究，通过随机数字列表法将所有患者随机分成研究组（n=40例）和对照组（n=40例）。研究组采用潘妥洛克静脉滴注治疗，对照组采用洛赛克静脉滴注治疗。观察和记录两组患者的临床治疗效果和不良反应发生情况，并进行比较分析。结果：两组患者的治疗有效率与不良反应发生率对比(P＞0.05)，均未出现血液系统与肝肾等严重不良反应。结论：潘妥洛克与洛赛克在消化性溃疡所致的上消化道出血患者的治疗中均具有良好的临床疗效，且安全性均比较好，值得在临床上推广应用。“,”Objective To observe and compare the clinical effect and adverse reaction observation of proton pump inhibitor pantoloc, omeprazole in the treatment of peptic ulcer caused by upper gastrointestinal bleeding.Methods 80 patients with the peptic ulcer caused by upper gastrointestinal bleeding and who accepted treatments in our hospital from July, 2013 to June, 2015 were taken as the research objects, and these patients were randomly divided into the study group(n=40) and the control group(n=40)by random number table method. In the study group, they were treated with the pantoloc intravenous infusion therapy while in the control group, they were treated with the omeprazole intravenous infusion therapy. Then, the clinical therapeutic effects and adverse reactions of two groups of patients were observed and recorded,and comparative analyzed.Resules In the comparation with the effective rate of treatment and adverse reactions of two groups of patients (P > 0.05), there were no serious adverse reactions such as blood system and liver and kidney.Conclusion The clinical effects of proton pump inhibitor pantoloc, omeprazole in the treatment of peptic ulcer caused by upper gastrointestinal bleeding are good enough, whichthe security is better, thus should be promoted in the clinical application.