论文部分内容阅读
本文研究了国产罗红霉素对３９１株临床分离菌的体外抗菌作用。研究结果表明，国产罗红霉素的抗菌作用与进口罗红霉素一致。罗红霉素对红霉素敏感的金葡球菌、表葡球菌、化脓链球菌、肺炎链球菌、粪链球菌、流感嗜血杆菌、淋病奈瑟氏球菌及厌氧菌有较好的抗菌作用，其ＭＩＣ５０分别为０．１２５、０．１２５、１、１、４、４、０．１２５、０，０６２ｍｇ／ Ｌ，细菌接种量对国产罗红霉素的体外抗菌作用因菌种不同而异，金葡球菌和表葡球菌不受接种量的影响，化脓链球菌和肺炎链球菌受接种量的影响较大。罗红霉素的体外抗菌作用受ｐＨ值的影响，ｐＨ７时对金葡球菌和表葡球菌的抗菌活性较ｐＨ６时明显增强。实验表明国产罗红霉素与红霉素有交叉耐药性。
In this paper, we studied the in vitro antibacterial activity of domestic roxithromycin against 391 clinical isolates. The results showed that the antibacterial effect of domestic roxithromycin was consistent with that of imported roxithromycin. Roxithromycin against erythromycin-sensitive Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus faecalis, Haemophilus influenzae, Neisseria gonorrhoeae and anaerobic bacteria have good antibacterial activity , The MIC50 were 0.125,0.125,1,1,4,4,0.125,0,062mg / L, inoculation capacity of inoculation of domestic roxithromycin in vitro antibacterial effect varies according to species Staphylococcus aureus and Staphylococcus epidermidis were not affected by inoculum size. Streptococcus pyogenes and Streptococcus pneumoniae were significantly affected by inoculum size. In vitro antibacterial activity of roxithromycin by the pH value of the impact of Staphylococcus aureus and Staphylococcus aureus at pH7 antibacterial activity was significantly enhanced compared to pH6. Experiments show that domestic roxithromycin and erythromycin cross-resistance.