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在研究抗高血压药物的动物试验中,降压效果和程度必须通过血压测量才能判断。动物试验测量血压的方法不外以盛抗凝液加压的导管插入动脉直接测量;及以橡皮带压迫肢体表浅动脉间接测量两种方法。直接测量虽便于连续描记,但往往须剖损血管,多系麻醉下进行,因此难免影响试验效果。且药物不便口服,粗制剂静脉注射杂质对血压常有影响。因此在筛试中药时,距离较大。而每一动物多仅供一两次试验,不能长期慢性观察。尤其目前狗猫等大动物来源困难,更难符合多、快、好、省的原
In animal studies on antihypertensive drugs, the effectiveness and extent of antihypertensive therapy must be measured by blood pressure. In animal experiments, the method of measuring blood pressure was measured either directly with a catheter inserted in an anticoagulant pressurized catheter or indirectly with a rubber band. Although the direct measurement of continuous tracing, but often need to cut blood vessels, multi-line anesthesia, it will inevitably affect the test results. Oral administration of drugs and inconvenience, crude intravenous injection of crude drugs often affect the blood pressure. Therefore, screening of traditional Chinese medicine, the greater the distance. And each animal only for one or two trials, can not be chronic long-term observation. In particular, at present, cats and other large animal sources are more difficult to meet with more, faster, better and provincial original