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目的:探讨甲襞微循环监测在嗜铬细胞瘤术前药物准备中的临床意义。方法:采取前瞻性自身对照研究,对20例嗜铬细胞瘤患者术前用竹林胺药物准备前、后,以及术后2~3个月,通过WXT-4型微循环图象计算机分析系统监测甲襞微循环,在微循环形态、血管流态、血管周围的情况三方面共22项指标进行定量分析与t检验。结果:20例患者经药物准备前后,在血管襻清晰度、管襻数、输入支管径、输出支管径、管襻长度、红细胞聚集程度、血色、形态积分、流态积分、总积分这10项微循环指标的统计学检验显示差异均有统计学意义(P<0.05或P>0.01);而手术前后微循环各项指标间差异无统计学意义。结论:甲襞微循环可以较好地反映全身微循环的状况,甲襞微循环监测可作为嗜铬细胞瘤术前准备的一项重要指标应用于临床。
Objective: To investigate the clinical significance of nailfold microcirculation monitoring in preoperative drug preparation of pheochromocytoma. Methods: A prospective self-controlled study was conducted in 20 patients with pheochromocytoma before and after pretreatment with bamboo amine drugs and 2 to 3 months after surgery. The WXT-4 microcirculation images were analyzed by computerized system Nail 襞 microcirculation, in the microcirculation morphology, blood flow, blood vessels around the three aspects of a total of 22 indicators for quantitative analysis and t test. Results: Before and after the drug preparation, there were no significant differences between the two groups in terms of clarity, number of tubes, diameter of input branch, diameter of branch tube, length of tube, erythrocyte aggregation, hemoglobin, morphological integral, fluidic integral, Statistical analysis of the 10 microcirculation indexes showed statistically significant differences (P <0.05 or P> 0.01). There was no significant difference between the indexes of microcirculation before and after operation. Conclusion: The microcirculation of formazan can better reflect the status of systemic microcirculation. The monitoring of microcirculation of formazan can be used as an important index for preoperative preparation of pheochromocytoma.