将12只家兔分为A,B两组,A组为健康对照组,B组注射四氯化碳,复制肝损伤模型。A,B两组家兔均以140 m g/kg(以磺胺六甲氧嘧淀(SMM)计)剂量耳静脉注射磺胺六甲氧嘧啶钠(SMM-N a),分别于给药后0.08,0.25,0.5,1,2,3,4,6 h采血0.5 mL,采用改良A nn ino法测定血液SMM浓度,以残数法逐只家兔拟合药-时曲线,并计算药物代泄动力学参数。结果表明,SMM在肝功能损害家兔体内的动力学变化明显,其动力学参数与健康时比较,t1/2β延长了5.087倍,AUC延长了3.051倍,tcp延长了3.753倍。表明家兔肝功能损害后,SMM在其体内消除显著变慢,提示在肝脏损害时应相应增大SMM给药时间间隔或减小给药剂量。 Twelve rabbits were divided into A and B groups. A group was healthy control group, B group was injected with carbon tetrachloride, liver injury model was duplicated. The rabbits in groups A and B were injected with SMM-N a at a dose of 140 mg / kg (as sulfamethoxazole (SMM)) via the ear vein, respectively, at 0.08, 0.25, 0.5, 1, 2, 3, 4, 6 h blood 0.5 mL, using a modified Anin ino method for the determination of blood SMM concentration by residue method by rabbit-only fitting drug-time curve and calculate the drug discharge dynamic parameters . The results showed that the dynamic changes of SMM in rabbits with hepatic dysfunction were obvious. The kinetic parameters of the SMM were 5.087-fold, 3.051-fold and 3.753-fold, respectively. After liver damage in rabbits showed that SMM in vivo elimination significantly slowed down, suggesting that the liver damage should be correspondingly increased SMM administration interval or reduce the dose.