Firstly, the cross large deflection equation of circular thin plate with variable thickness in rectangular coordinates system was transformed into unsymmetrical large deflection equation of circular thin plate with variable thickness in polar coordinates system.This cross equation in polar coordinates system is united with radical and tangential equations in polar coordinates system, and then three equilibrium equations were obtained. Physical equations and nonlinear deformation equations of strain at central plane are substituted into superior three equilibrium equations, and then three unsymmetrical nonlinear equations with three deformation displacements were obtained. Solution with expression of Fourier series is substituted into fundamental equations; correspondingly fundamental equations with expression of Fourier series were obtained. The problem was solved by modified iteration method under the boundary conditions of clamped edges. As an example, the problem of circular thin plate with variable thickness subjected to loads with cosin form was studied.Characteristic curves of the load varying with the deflection were plotted. The curves vary with the variation of the parameter of variable thickness. Its solution is accordant with physical conception.