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目的 :探索活血止痛液制备的最佳工艺。方法 :采用了正交设计法考察乙醇的提取浓度、用量、提取次数及时间 4个因素 ,以甲醇浸出物与阿魏酸的含量为考察指标 ,同时采用高效液相法测定成品中阿魏酸的含量。结果 :最佳制备工艺为 4倍量 6 0 %乙醇回流提取 3次 ,每次 2h。测定活血止痛液 1ml中阿魏酸含量≥ 0 .0 5mg。 结论 :制剂稳定 ;测定方法简便、灵敏、准确、重复性好
Objective : To explore the best preparation of Huoxuezhitong preparation. Methods: The orthogonal design method was used to study the four factors of ethanol concentration, dosage, extraction times and time. The contents of methanol extract and ferulic acid were used as indicators, and the ferulic acid in the finished product was determined by HPLC. The content. Results : The optimal preparation process was 4 times 60% ethanol reflux extraction 3 times for 2 hours. The content of ferulic acid in 1 ml of blood circulation and analgesic solution was ≥ 0.05 mg. Conclusion: The preparation is stable; the method is simple, sensitive, accurate and reproducible