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本研究应用国产盐酸纳曲酮对86例临床脱毒后的阿片类依赖者进行了6 -12mon临床观察,并随机挑选同期入院未接受纳曲酮治疗的86例阿片类依赖者作为对照,结果表明:试验组服用纳曲酮平均保持时间83.1d±s59.1d、比既往脱毒后平均操守时间9.44d±s17.70d明显延长,自身对照有非常显著差异;保持不复吸平均时间164.1d±s105d,比对照组保持不复吸平均时间48.84d±s94.84d明显延长,同期对照亦有非常显著差异。高剂量组服药人数保持率高于中剂量和低剂量组,合适剂量应为40 -50mg。研究表明:国产纳曲酮能明显降低复吸率,不良反应轻,用于脱毒后的巩固治疗有明显疗效。
In this study, domestic naltrexone hydrochloride 86 cases of clinical detoxification of opiate dependent 6 -12mon clinical observation, and were randomly selected during the same period did not receive naltrexone 86 opiate dependent as a control, the results The results showed that: the experimental group took naltrexone average retention time of 83.1d ± s59.1d, compared with the past detoxification after the average conduct time of 9.44d ± s17.70d significantly prolonged self-control has a very significant difference; to keep the average recovery time 164.1d ± s105d, compared with the control group to maintain the average duration of 48.84d ± s94.84d prolonged significantly over the same period the control also has a very significant difference. High-dose group of drug retention was higher than the medium-dose and low-dose group, the appropriate dose should be 40 -50mg. Studies have shown that: domestic naltrexone can significantly reduce the rate of relapse, adverse reactions, for the consolidation after detoxification have a significant effect.