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目的：探讨血浆血小板α颗粒膜蛋白（Ｇμｐ－１４０）水平的变化在原发性肾病综合征（ＰＮＳ）中的意义。方法：用放免法测定了２４例ＰＮＳ病人和２０例正常的血浆ＧＭＰ－１４０水平，同时测定末梢血小板（ＰＬＴ）计数、血浆凝血酶原时间（ＰＴ）、血浆纤维蛋白原（Ｆｉｂ）定量、血及尿中纤维蛋白（原）降解产物（ＦＤＰ）。结果：ＰＮＳ病人血浆ＧＭＰ－１４０水平高于正常对照组（Ｐ＜０．０５），同时ＰＬＴ、血浆Ｆｉｂ、尿ＦＤＰ水平明显升高（Ｐ＜０．０１）。ＰＮＳ病人血浆ＧＭＰ－１４０水平与２４ｈ尿蛋白定量呈正相关（γ＝０．５６，Ｐ＜０．０１）。结果：血浆ＧＭＰ－１４０水平是反映血小板活化的良好指标，血小板活化与肾小球滤过屏障损伤有关。
Objective: To investigate the significance of plasma platelet α-granule membrane protein (Gμp-140) level in primary nephrotic syndrome (PNS). Methods: 24 cases of PNS and 20 cases of normal plasma GMP-140 levels were determined by radioimmunoassay. Meanwhile, peripheral blood platelet (PLT) count, plasma prothrombin time (PT), plasma fibrinogen (Fib) And urinary fibrin (prot) degradation products (FDP). Results: The plasma level of GMP-140 in patients with PNS was significantly higher than that in normal controls (P <0.05). PLT, plasma Fib and urinary FDP levels were significantly increased (P <0.01). PNS patients with plasma GMP-140 levels and 24h urinary protein was positively correlated (γ = 0.56, P <0.01). Results: Plasma GMP-140 level was a good indicator of platelet activation, and platelet activation was related to the damage of glomerular filtration barrier.