目的探讨重症肌无力OssermanⅤ型的临床表现及误诊原因。方法对2例重症肌无力Os-sermanⅤ型病例进行回顾性分析。结果2例均表现为言语鼻音、舌肌萎缩、吞咽困难,其临床症状与多种疾病有相似之处,极易误诊;本2例患者均长期未明确诊断并被误诊,最终经新斯的明试验和肌电图明确诊断;给予胆碱酯酶抑制剂和激素治疗后病情明显好转。结论掌握重症肌无力OssermanⅤ型的临床特点和规范化的诊疗程序是减少误诊的有效措施。 Objective To investigate the clinical manifestations and misdiagnosis of Osserman Ⅴ in myasthenia gravis. Methods Two cases of myasthenia gravis type Os-serman were retrospectively analyzed. Results Both of the two cases showed verbal nasal tone, tongue atrophy and swallowing difficulties. Their clinical symptoms were similar to those of many diseases and were easily misdiagnosed. Both of these two cases were not diagnosed for the long term and were misdiagnosed. Finally, Ming test and EMG clear diagnosis; given cholinesterase inhibitors and hormone therapy after the condition improved significantly. Conclusion To master the clinical features of Osserman type Ⅴ and to standardize the diagnosis and treatment procedures is an effective measure to reduce misdiagnosis.