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目的探讨加味水陆二仙丹对实验性糖尿病大鼠血脂的影响,以及对肝脏的保护作用。方法采用高脂高热量饮食结合一次性腹腔注射1%链脲佐菌素(STZ)溶液35 mg/kg,建立2型糖尿病SD大鼠模型,随机分为模型组、罗格列酮组、中药治疗组,每组8只,另取8只正常大鼠作为对照,正常组给予基础饲料喂养,其余组给予高脂高热量饲料饲养,药物干预4周后,观察并比较各组大鼠血脂、血糖、胰岛素水平及肝组织形态学变化。结果与模型组比较,加味水陆二仙丹能显著降低大鼠肝重指数、TC、LDL-C、TG、血清胰岛素水平、肝细胞脂肪变程度,差异均有统计学意义(P<0.05)。结论加味水陆二仙丹可在一定程度上缓解非酒精性脂肪性肝病(NAFLD)病理学改变,可能与其能降低血脂水平有关,改善高胰岛素血症可能是加味水陆二仙丹防治NAFLD的作用机制之一。
Objective To investigate the effects of flavored Rhodiola on blood lipids in rats with experimental diabetes mellitus and its protective effects on the liver. Methods A high-fat and high-calorie diet combined with a single intraperitoneal injection of 1% streptozotocin (STZ) solution 35 mg / kg was used to establish a rat model of type 2 diabetes. The rats were randomly divided into model group, rosiglitazone group, The treatment group, 8 rats in each group, another 8 normal rats as control, the normal group was given basal diet, the rest were given high-fat and high-calorie feed, 4 weeks after drug intervention, the blood lipid, Blood glucose, insulin levels and liver histological changes. Results Compared with the model group, flavonoids Rhizoma Decoction could significantly reduce the liver weight index, TC, LDL-C, TG, serum insulin, hepatocellular steatosis, the difference was statistically significant (P <0.05). Conclusions Flavored amphioxus can alleviate the pathological changes of non-alcoholic fatty liver disease (NAFLD) to a certain degree, which may be related to its ability to reduce blood lipid levels. Improving hyperinsulinism may be one of the mechanisms of NAFLD .