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目的研究儿童细菌性肺炎治疗中利用血清降钙素原水平指导临床抗生素使用的价值。方法将92例儿童细菌性肺炎患儿随机分为对照组和治疗组。对照组给予经验治疗,治疗组应用血清降钙素原含量指导抗生素应用治疗。比较两组抗生素使用时间、抗生素使用费用及细菌耐药率的差异。结果两组患儿在抗生素使用时间上,对照组(6.3±0.4)d与治疗组(3.6±0.5)d相比,差异有统计学意义(P<0.05);两组在抗生素使用费用上,对照组(951±85)元与治疗组(493±66)元相比,差异有统计学意义(P<0.05)。两组在平均细菌耐药率上,对照组平均20.5%与治疗组10.4%相比,差异有统计学意义(P<0.05)。结论儿童细菌性肺炎治疗中参考血清降钙素原水平用药,可以在达到更好治疗效果的同时减少抗生素的使用时间、费用和细菌耐药率。
Objective To study the value of using serum procalcitonin in the treatment of bacterial pneumonia in children to guide the clinical use of antibiotics. Methods Ninety-two children with bacterial pneumonia were randomly divided into control group and treatment group. The control group was given empirical treatment, and the treatment group used the serum procalcitonin content to guide the antibiotic treatment. The differences of antibiotic use time, antibiotic use cost and bacterial resistance rate were compared between the two groups. Results Compared with the treatment group (3.6 ± 0.5) d, the differences of the antibiotic use time between the two groups were statistically significant (P <0.05) The difference between the control group (951 ± 85) yuan and the treatment group (493 ± 66) yuan was statistically significant (P <0.05). The average bacterial resistance rate of the two groups, the control group averaged 20.5% compared with the treatment group 10.4%, the difference was statistically significant (P <0.05). Conclusions The reference serum procalcitonin level in the treatment of bacterial pneumonia in children can achieve better therapeutic effect and reduce the antibiotic use time, cost and bacterial resistance rate.