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目的探讨综合治疗对冠心病患者血浆肿瘤坏死因子-α(TNF-α)和单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)水平的影响。方法选取2012年10月—2014年9月收治的174例冠心病患者作为研究对象,随机分成A组和B组各87例。B组予以常规治疗方案,A组在常规治疗基础上联合阿托伐他汀钙片+通心络胶囊。检测并记录两组患者治疗前后TNF-α及MCP-1等炎症因子水平变化情况,对比其临床疗效,分析治疗前后各血脂指标改善情况。计量资料组间比较采用t检验,组内比较采用配对t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果 A组治疗总有效率为89.7%,显著高于B组的71.3%,差异有统计学意义(P<0.05)。治疗后,A组与B组TNF-α、MCP-1水平分别为(14.9±5.1)ng/L、(10.2±3.4)pg/L、(17.5±4.4)ng/L、(14.3±3.8)pg/L,均显著低于治疗前的(20.8±3.8)ng/L、(18.4±2.9)pg/L、(20.9±3.8)ng/L、(18.5±2.8)pg/L,差异均有统计学意义(均P<0.05)。两组治疗后TNF-α、MCP-1水平比较差异均有统计学意义(均P<0.05)。治疗后,A组与B组TC、TG、LDL-C水平分别为(4.5±0.5)、(1.3±0.2)、(2.1±0.4)、(5.0±0.5)、(1.6±0.3)、(2.6±0.3)mmol/L,均显著低于治疗前的(5.6±0.8)、(1.8±0.8)、(2.7±0.7)、(5.5±0.9)、(1.8±0.7)、(2.6±0.8)mmol/L,差异均有统计学意义(均P<0.05)。两组治疗后TC、TG、LDL-C水平比较差异均有统计学意义(均P<0.05)。结论对冠心病患者予以综合治疗方案,疗效确切,可有效促进病情转归,对改善患者炎性反应、调节血脂水平等具有积极意义,值得临床推广应用。
Objective To investigate the effect of comprehensive treatment on plasma levels of tumor necrosis factor-α (TNF-α) and monocyte chemotactic protein-1 (MCP-1) in patients with coronary heart disease. Methods A total of 174 patients with coronary heart disease admitted in our hospital from October 2012 to September 2014 were randomly divided into group A and group B (n = 87). Group B was given routine treatment, group A was treated with atorvastatin calcium + Tongxinluo capsule on the basis of routine treatment. The levels of TNF-α and MCP-1 and other inflammatory cytokines in the two groups before and after treatment were measured and recorded. The clinical efficacy was analyzed and compared. Measurement data were compared between groups using t test, the group was compared using paired t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate of treatment in group A was 89.7%, which was significantly higher than that in group B (71.3%), the difference was statistically significant (P <0.05). After treatment, the levels of TNF-α and MCP-1 in group A and group B were (14.9 ± 5.1) ng / L, (10.2 ± 3.4) pg / L, (20.8 ± 3.8) ng / L, (20.9 ± 3.8) ng / L and (18.5 ± 2.8) pg / L before treatment were significantly lower than those before treatment (P < Statistical significance (all P <0.05). The levels of TNF-α and MCP-1 in two groups after treatment were significantly different (all P <0.05). The levels of TC, TG and LDL-C in group A and group B were (4.5 ± 0.5), (1.3 ± 0.2), (2.1 ± 0.4), (5.0 ± 0.5), (1.6 ± 0.3) and ± 0.3) mmol / L were significantly lower than those before treatment (5.6 ± 0.8, 1.8 ± 0.8, 2.7 ± 0.7, 5.5 ± 0.9, 1.8 ± 0.7, 2.6 ± 0.8, / L, the differences were statistically significant (all P <0.05). The levels of TC, TG and LDL-C in both groups after treatment were significantly different (all P <0.05). Conclusion Comprehensive treatment of patients with coronary heart disease, the curative effect is exact, which can effectively promote the prognosis of patients, which has positive significance for improving inflammatory response and regulating blood lipid level in patients. It is worthy of clinical application.