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目的观察去甲肾上腺素联合小剂量硝酸甘油治疗老年人感染性休克的疗效。方法 80例老年人感染性休克患者随机分为两组,观察组40例,对照组40例,两组均采用复苏目标导向、抗感染及去甲肾上腺素治疗,观察组在此基础上加用小剂量硝酸甘油。两组共治疗7d。测定患者的血流动力学和乳酸清除率。结果治疗7d后,两组心排出量指数(CI)明显降低,外周血管阻力指数(SVRI)均有明显升高,并且观察组比对照组升高更明显。两组的乳酸清除率均明显升高,观察组高于对照组(P<0.05)。结论去甲肾上腺素联合小剂量硝酸甘油对老年人感染性休克效果更明显。
Objective To observe the efficacy of norepinephrine combined with small doses of nitroglycerin in the treatment of septic shock in the elderly. Methods A total of 80 elderly patients with septic shock were randomly divided into two groups: 40 cases in the observation group and 40 cases in the control group. Both groups were treated with recovery-oriented, anti-infective and norepinephrine treatment. The observation group was added on the basis of this Small doses of nitroglycerin. The two groups were treated for 7 days. The patient’s hemodynamics and lactate clearance were determined. Results After 7 days of treatment, both the cardiac output index (CI) and the peripheral vascular resistance index (SVRI) were significantly increased, and the observation group was more obvious than the control group. Lactic acid clearance rate of both groups were significantly increased, the observation group was higher than the control group (P <0.05). Conclusion Norepinephrine combined with small doses of nitroglycerin is more effective in septic shock in the elderly.