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目的观察中药复方益气活血解毒汤对实验性动脉粥样硬化(AS)家兔C反应蛋白(CRP)及主动脉斑块的干预作用及其机制。方法24只日本雄性大耳白兔随机分为正常对照组、模型对照组、益气活血解毒汤组、辛伐他汀组。采用高脂饲料喂饲建立兔AS模型,其中益气活血解毒汤组及辛伐他汀组造模同时灌胃相应药液,而前两组以等量蒸馏水灌胃。10周后测定各组家兔斑块面积及血清CRP的含量。结果模型对照组CRP较正常对照组升高,益气活血解毒汤组及辛伐他汀组CRP明显低于模型组,与正常对照组相近。模型对照组斑块面积较空白对照组明显升高,益气活血解毒汤组及辛伐他汀组斑块面积均低于模型对照组,益气活血解毒汤组斑块面积与辛伐他汀组比较有所降低。结论益气活血解毒汤对AS有明显的预防和治疗作用,其可减少斑块的面积,降低血清CRP含量,从而起到稳定AS斑块的作用。
OBJECTIVE: To observe the intervention effect of Yiqi Huoxue Jiedu Decoction, a traditional Chinese compound compound, on C reactive protein (CRP) and aortic plaque in rabbits with experimental atherosclerosis (AS) and its mechanism. Methods Twenty-four Japanese male rabbits were randomly divided into normal control group, model control group, Yiqi Huoxue Jiedu Decoction group, and simvastatin group. Rabbit model of AS was established by feeding high-fat diets. The Yiqi Huoxue Jiedu Decoction group and the simvastatin group were given intragastric administration of the corresponding liquids at the same time, while the first two groups were fed with the same volume of distilled water. After 10 weeks, the plaque area and serum CRP levels in rabbits were determined. Results The CRP in the model control group was higher than that in the normal control group. The CRP in the Yiqi Huoxue Jiedu Decoction group and the simvastatin group was significantly lower than that in the model group, which was similar to the normal control group. The plaque area of the model control group was significantly higher than that of the blank control group. The plaque area of the Yiqi Huoxue Jiedu Decoction group and the simvastatin group was lower than that of the model control group. The plaque area of the Yiqi Huoxue Jiedu Decoction group was compared with the simvastatin group. Have decreased. Conclusion Yiqi Huoxue Detoxification Decoction has obvious preventive and therapeutic effects on AS, which can reduce the area of plaque and reduce serum CRP content, so as to stabilize the AS plaque.