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目的:探讨间皮素mRNA（MESO mRNA）、KISS1 mRNA在上皮性卵巢癌（EOC）中的表达及与预后的相关性。方法:选取2017年1月至2019年1月河北省唐山市妇幼保健院52例EOC患者作为观察组，另选取52例同期健康体检者作为对照组，对比两组血MESO mRNA、KISS1 mRNA表达水平；分析MESO mRNA、KISS1 mRNA水平与EOC的关系；分析EOC患者MESO mRNA、KISS1 mRNA水平与临床病理学特征的相关性；对EOC患者随访1年，对比不同预后患者MESO mRNA、KISS1 mRNA的表达情况。结果:观察组血MESO mRNA、KISS1 mRNA水平高于对照组（1.41 ± 0.40比1.41 ± 0.40、0.73 ± 0.08比0.54 ± 0.07），差异有统计学意义（n P<0.01）。MESO mRNA、KISS1 mRNA联合诊断EOC的曲线下面积（AUC）为0.892（95%n CI 0.816～0.944），高于MESO mRNA、KISS1 mRNA单一诊断的AUC 0.798（95% n CI 0.708～0.870）、0.812（95% n CI 0.723～0.882）。血MESO mRNA水平与EOC患者病理类型、手术-病理分期、病理分级、肿瘤直径、淋巴结转移存在相关性（n P<0.05）；血KISS1 mRNA水平与EOC患者手术-病理分期、病理分级、肿瘤直径、淋巴结转移存在相关性（n P<0.05）。死亡者血MESO mRNA水平高于生存者（1.52 ± 0.17比1.38 ± 0.15），血KISS1 mRNA水平低于生存者（0.69 ± 0.07比0.74 ± 0.06），差异有统计学意义（n P<0.05）；随访1年，血MESO mRNA高表达者1年生存率低于低表达者，KISS1 mRNA高表达者1年生存率高于低表达者（n P<0.05）。n 结论:EOC患者外周血MESO mRNA、KISS1 mRNA表达升高，但随病情进展MESO mRNA呈升高趋势，KISS1 mRNA呈降低趋势，二者异常表达可能参与EOC发生发展。“,”Objective:To investigate the expression of mesothelin mRNA (MESO mRNA) and tumor metastasis suppressor gene KISS1 mRNA in epithelial ovarian cancer (EOC) and its correlation with prognosis.Methods:From January 2017 to January 2019, 52 patients with EOC in Tangshan Maternal & Child Health Care Hospital were selected as the observation group, and 52 healthy controls were selected as the control group. The levels of MESO mRNA and KISS1 mRNA between the two groups were compared; the correlation of MESO mRNA and KISS1 mRNA and EOC were analyzed; the correlation between MESO mRNA and KISS1 mRNA and clinicopathological characteristics was analyzed, and the expression of MESO mRNA and KISS1 mRNA in patients with different prognosis was compared after followed up for 1 year.Results:The levels of MESO mRNA and KISS1 mRNA in the observation group were higher than those in the control group (1.41 ± 0.40 vs. 1.41 ± 0.40, 0.73 ± 0.08 vs. 0.54 ± 0.07), and the differences were statistically significant (n P<0.05). The area under the curve(AUC) of combined diagnosis of EOC with MESO mRNA and KISS1 mRNA was 0.892 (95%n CI 0.816 - 0.944), which was higher than the AUC of MESO mRNA and KISS1 mRNA single diagnosis ,which were 0.798 (95% n CI 0.708 - 0.870), and 0.812 (95% n CI 0.723 - 0.882). The differences of blood MESO mRNA level in different pathological types, operations-pathological stage, pathological grade, tumor diameter, lymph node metastasis were statistically significant (n P<0.05); the differences of blood KISS1 mRNA level in different operations-pathological stage, pathological grade, tumor diameter, lymph node metastasis were statistically significant (n P<0.05). The blood MESO mRNA level of the dead was higher than that of the survivors(1.52 ± 0.17 vs. 1.38 ± 0.15), the blood KISS1 mRNA level was lower than that of the survivors (0.69 ± 0.07 vs. 0.74 ± 0.06), and the differences were statistically significant (n P<0.05).The 1-year survival rate of patients with high expression of blood MESO mRNA was lower than that with low expression, and the 1-year survival rate of patients with high expression of KISS1 mRNA was higher than that with low expression (n P<0.05).n Conclusions:The expression of MESO mRNA and KISS1 mRNA in the peripheral blood of patients with EOC is increased, but with the progression of the disease, MESO mRNA is increased and KISS1 mRNA is decreased. The abnormal expression of the two may participate in the development of EOC.