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目的:观察咖啡酸锗对小鼠子宫颈癌14号(U14)的作用。方法:以无菌生理盐水按1∶3稀释,调整细胞数约为2.08×109个/L,于每只小鼠右肢皮下接种0.2mLU14,以咖啡酸锗高、中、低3个剂量连续给药10d,以生理盐水组为模型对照组,计算各剂量组对U14的抑制率。结果:咖啡酸锗高、中剂量对U14有较好的抑制率,低剂量也有一定的抑制作用,且给药前后小鼠体重明显增加。结论:咖啡酸锗对小鼠U14有抑制作用,且毒性很小。
Objective: To observe the effect of caffeic acid germanium on mouse cervical cancer 14 (U14). METHODS: The cells were diluted 1: 3 with sterile saline and the number of cells was adjusted to 2.08 × 109 cells / L. 0.2 mL of U14 was subcutaneously inoculated to the right limbs of each mouse. Administered for 10 days, the saline group as a model control group, calculate the inhibition rate of each dose group of U14. Results: High and medium doses of caffeic acid germanium had a better inhibition rate on U14 and lower dose, and the weight of mice before and after administration was significantly increased. Conclusion: Caffeic acid and germanium have inhibitory effects on mouse U14 with little toxicity.