论文部分内容阅读
目的 :建立 SD鼠脊髓下行传导束诱发电位 ( MEP)模型。 方法 :刺激颈髓段下行传导束 ,于双侧坐骨神经记录电位变化。采用 8个不同刺激强度区间 ,并结合脊髓部分损伤状态 ,评价其潜伏期和波幅的变化。结果 :诱发电位主要由 3个正负波峰组成。 N1的潜伏期 :右侧 ( 2 .89± 0 .2 2 ) ms,左侧 ( 2 .89± 0 .2 4) ms。传导速度 47.9m/s。 N1的波幅 :右侧 ( 3 .61± 2 .10 )μV,左侧 ( 3 .83± 2 .3 2 )μV。不同刺激强度组间潜伏期相差不显著 ,但组间波幅有显著性差异 (右侧 F =2 .2 2 ,df =72 0 1,P=0 .0 3 ;左侧 F =2 .11,df=72 0 6,P=0 .0 4)。 T9平面脊髓部分损伤后 ,潜伏期延长 ,右侧 14 % ,左侧 12 % ;波幅下降 ,右侧5 9 % ,左侧 3 1%。结论 :建立的颈髓段下行传导束诱发电位动物模型有效、可靠 ,重复性好。用此模型可准确地检测脊髓传导束的功能状态
Objective: To establish the model of spinal cord evoked potentials (MEP) in SD rats. Methods: Stimulate the descending cervical spinal cord conduction line, in bilateral sciatic nerve changes in recording potential. Eight different stimulation intensity intervals were used, and the changes of the latency and amplitude of spinal cord were evaluated in combination with partial spinal cord injury. Results: The induced potential mainly consists of three positive and negative peaks. The latency of N1 was (2.89 ± 0.22) ms on the right and (2.89 ± 0.24) ms on the left. Conduction speed 47.9m / s. Amplitude of N1: right (3.61 ± 2.10) μV, left (3.83 ± 2.32) μV. There was no significant difference in latency between different stimulation intensity groups, but there was significant difference between the two groups (F = 2.22 on the right, df = 72 0 1, P = 0. 03 on the left, F = 2.11 on the left, df = 72 0 6, P = 0. 0 4). After partial spinal cord injury of T9, the latency period was prolonged, with 14% on the right and 12% on the left; amplitude decreased, 59% on the right and 31% on the left. Conclusion: The established animal model of spinal cord evoked potentials in the cervical cord segment is effective, reliable and reproducible. Use this model to accurately detect the functional status of the spinal cord