论文部分内容阅读
目的 研究尿激酶型纤维溶酶原激活剂受体（uPAR）在儿童髓母细胞瘤中的表达及其与预后的关系。方法 采用免疫组化法检测84例经手术病理证实并获随访的儿童髓母细胞瘤（男46例,女38例,年龄6～12岁）中uPAR表达,按术后生存期3、5、10年,分为A、B和C组,使用Cox回归统计分析。结果84例儿童髓母细胞瘤中,uPAR阳性表达64例（76％）,A、B和C组间uPAR阳性表达分别为95％、67％和40％（P<0.01）;Cox回归分析显示uPAR是影响生存时间的一个独立的预后因子,它与预后存在高度负相关性。结论uPAR表达水平同儿童髓母细胞瘤预后密切相关。
Objective To study the expression of urokinase-type plasminogen activator receptor (uPAR) in childhood medulloblastoma and its relationship with prognosis. Methods Immunohistochemical method was used to detect the expression of uPAR in 84 cases of medulloblastoma (46 males and 38 females, aged 6-12 years) confirmed by surgery and pathology. The survival rates were 3, 5, Ten years, divided into groups A, B and C using Cox regression analysis. Results The positive expression of uPAR in 84 cases of children with medulloblastoma was 64 cases (76%), and the positive expression of uPAR in group A, B and C was 95%, 67% and 40% respectively (P <0.01). Cox regression analysis uPAR is an independent prognostic factor that affects survival, which is highly negatively correlated with prognosis. Conclusion The expression level of uPAR is closely related to the prognosis of childhood medulloblastoma.