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目的讨论脑白质疏松症(leukoaraiosis,LA)的发生机理,探讨LA和认知功能损害之间的联系;探究LA患者认知功能与脑血管收缩期峰值血流速度之间的联系。方法把61例LA患者编入被试对象。对被试对象进行分组,根据简明精神状态量表(mini-mental examination,MMSE)进行划分。认知障碍组16人。认知正常组45人。让被试对象均接受经颅多普勒超声(transcranial doppler ultrasound,TCD)检查,接受神经认知心理学测试,包括MMSE、词汇流畅性试验(vocabulary fluency test,VFT)、数字广度试验(digit span test,DS),记录检测结果。结果大脑前动脉(anterior cerebral artery,ACA)的收缩期峰值血流速度(peak systolic velocity,PSV)两组相比,认知正常组大于认知障碍组(Z=-2.275,P=0.023)。余所检测血管的PSV差异均无统计学意义(均有P>0.05)。结论LA和认知功能异常有密切联系。LA病人额叶认知功能下降。ACA正是额叶供血的主要血管,ACA的PSV出现降低,推测其额叶认知功能与ACA的PSV降低有关。
Objective To discuss the mechanism of leukoaraiosis (LA) and to explore the relationship between LA and cognitive impairment. To explore the relationship between cognitive function and peak systolic blood flow velocity in LA patients. Methods 61 cases of LA patients were enrolled in the subjects. Subjects were divided into groups according to the mini-mental examination (MMSE). 16 people with cognitive impairment. Cognitive group of 45 people. Subjects underwent transcranial doppler ultrasound (TCD) examinations and underwent neurocognitive psychology tests including MMSE, Vocabulary fluency test (VFT), digit span test, DS), record the test results. Results Compared with cognitive impairment group (P <0.05), cognitive cognitive impairment group (Z = -2.275, P = 0.023) showed significantly higher peak systolic velocity (PSV) in anterior cerebral artery (ACA) There was no significant difference in PSV among the detected blood vessels (all P> 0.05). Conclusion LA and cognitive dysfunction are closely linked. LA patients with frontal lobe cognitive decline. ACA is the main blood supply in the frontal lobe, ACA PSV decreased, suggesting that the frontal lobe cognitive function and ACA PSV decreased.