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5. Detection of two amino acid deletions in HIV-1 Nef protein from Chinese former paid blood donors

Detection of two amino acid deletions in HIV-1 Nef protein from Chinese former paid blood donors

来源 :中华医学杂志 | 被引量 : 0次 | 上传用户：dgp000

【摘 要】

：

HIV-1 Nef protein plays an important role in HIV-1 pathogenesis, including downregulation of the cell surface CD4 and class Ⅰ major histocompatibility complex

【作 者】

：

SONG Yan-hui WEI Min MA Peng-f 

【机 构】

：

Wuhan Institute of Virology,Graduate School of the Chinese Academy of Sciences,State Key Laboratory

【出 处】

：

中华医学杂志

【发表日期】

：

2004年期

【关键词】

：

human immunodeficiency virus nef disease progression 

【基金项目】

：

国家重点基础研究发展计划(973计划);the NIH CIPRA;the National Outstanding Youth Grant

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论文部分内容阅读

HIV-1 Nef protein plays an important role in HIV-1 pathogenesis, including downregulation of the cell surface CD4 and class Ⅰ major histocompatibility complex (MHC), enhancement of virion infectivity and alteration of a variety of cellular signal transduction pathways.

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