中草药有效成分复杂,一般含有多种成分或成分未明,故难以用现有的化学手段检测其血药浓度,当然更谈不上据此计算其药动学参数了。我们提出了用动物死亡率法估测药动学参数的方法,此法具有非特异,通用的性质,只要能使动物急性致死的药物,都可以用本法估计其药动学参数,而不论其成分如何以及是否单一等,故很适用于各种中草药的估测。今结合中草药的一般特点对本法进行介绍。 方法 原理 通过两次给药观察动物死亡率可以测定药物在体内的蓄积性,但这只能测得一个特定时间的蓄积率,并且过去方法的两 The active ingredients of Chinese herbal medicines are complex and generally contain multiple components or components that are not known. Therefore, it is difficult to measure the blood drug concentration using the existing chemical methods. Of course, the pharmacokinetic parameters of these herbs cannot be calculated. We proposed a method of estimating pharmacokinetic parameters using the animal mortality method. This method has non-specific and universal properties. As long as the drug can make animals acutely lethal, the pharmacokinetic parameters can be estimated by this method, regardless Its composition and how it is single, so it is suitable for a variety of Chinese herbal medicines to estimate. This law is introduced by combining the general characteristics of Chinese herbal medicines. METHODS PRINCIPLE The accumulation of drugs in the body can be determined by observing the mortality of animals by two administrations, but this can only measure the accumulation rate at a specific time, and the two methods of the past