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目的探讨盐酸替罗非班(血小板Ⅱb/Ⅲa受体拮抗剂)及血栓抽吸能否有效减少急性心肌梗死介入治疗中慢血流或无复流现象的发生。方法选择急性心肌梗死患者55例,分为单纯经皮冠状动脉介入治疗(PCI)17例(A组)、PCI+盐酸替罗非班治疗20例(B组)、PCI+血栓抽吸治疗18例(C组),比较三组在急性心肌梗死介入治疗中慢血流或无复流发生率。结果 A组慢血流或无复流发生4例(23.5%),B组1例(5.0%),C组1例(5.6%)(P<0.05)。与A组比较,B、C组ST段70%回落发生率升高,肌酸激酶心肌型同工酶(CK-MB)及肌钙蛋白I(TnI)峰值水平下降(P<0.05)。结论Ⅱb/Ⅲa受体拮抗剂及血栓抽吸可能减少急性心肌梗死患者PCI术中的慢血流或无再流现象。
Objective To investigate whether tirofiban hydrochloride (platelet Ⅱ b / Ⅲ a receptor antagonist) and thrombus aspiration can effectively reduce the occurrence of slow or no-reflow in the interventional treatment of acute myocardial infarction. Methods A total of 55 patients with acute myocardial infarction (AMI) were enrolled in this study. All patients were divided into two groups: PCI (A group), PCI + Tirofiban 20 (B group) and PCI + thrombus aspiration Group C). The incidence of slow or no reflow in the interventional treatment of acute myocardial infarction was compared between the three groups. Results A group of slow or no reflow occurred in 4 cases (23.5%), B group in 1 case (5.0%) and C group in 1 case (5.6%) (P <0.05). Compared with group A, the incidence of 70% drop in ST segment of group B and C increased, and the peak of CK-MB and TnI decreased (P <0.05). Conclusions Ⅱb / Ⅲa receptor antagonists and thrombus aspiration may reduce the slow or no reflow during PCI in patients with acute myocardial infarction.