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目的:测定本院3种品牌奥美拉唑肠溶胶囊的含量、耐酸度和释放度,观察其存在的差异、为本院临床合理用药及医院药品引进提供参考。方法:使用高效液相色谱法(HPLC)对3种品牌的奥美拉唑肠溶胶囊的含量、耐酸度和释放度进行测定,通过方差分析及t检验等统计学方法对结果进行验证。结果:国产与进口奥美拉唑肠溶胶囊含量、释放度和耐酸度均符合规定,但国产与进口奥美拉唑的释放度和耐酸度差异有统计学意义(P<0.05)。结论:国产与进口奥美拉唑肠溶胶囊的释放度和耐酸度具有差异性。
OBJECTIVE: To determine the content, acidity and release of omeprazole enteric-coated capsules in three kinds of hospitals in our hospital and to observe the differences in the existence of omeprazole enteric-coated capsules for hospital clinical rational drug use and hospital drug introduction. Methods: The content, acidity and release of omeprazole enteric-coated capsules of three brands were determined by high performance liquid chromatography (HPLC). The results were verified by statistical methods such as analysis of variance and t-test. Results: The content, release and acidity of omeprazole in domestic and imported omeprazole were both in accordance with the regulations, but the differences of release and acidity of omeprazole between domestic and imported omeprazole were statistically significant (P <0.05). Conclusion: The release and acidity of domestic and imported omeprazole enteric-coated capsules are different.