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用微量淋巴细胞毒试验测定45例分裂情感性精神病(Schizoaffective psychosis,简称SAP)患者的人体白细胞A位点抗原(HLA-A)和B位点抗原(HLA-B)。与289例随机抽样的无血缘关系的健康对照组相比,发现SAP患者HLA-A_2抗原的表现型频度降低和B_5抗原的表现型频度增高有显著差异,各为49.28％和31.11％,10.59％和26.67％。与文献资料相比,我们认为它兼具精神分裂症患者HLA-A_2频度较低和情感性精神病患者HLA-B_5频度较高的特点。提示本病可能是介于精神分裂症和情感性精神病之间的一种“谱群疾病”。从临床、遗传学角度看,精神分裂症、情感性精神病和SAP在发病上具有同一生物学基础。
A total of 45 patients with schizoaffective psychosis (HLA) were tested for HLA-A and HLA-B antigens by using the microcytotoxicity assay. Compared with 289 unrelated healthy controls, there was a significant difference in the frequency of HLA-A 2 antigen expression and the frequency of B 5 antigen phenotype in SAP patients (49.28% and 31.11%, respectively) 10.59% and 26.67%. Compared with the literature, we think it has both the lower frequency of HLA-A 2 and the higher frequency of HLA-B 5 in patients with schizophrenia. Suggesting that the disease may be between the schizophrenia and emotional psychosis, a “spectrum disease.” From a clinical and genetic point of view, schizophrenia, affective psychosis and SAP have the same biological basis in the pathogenesis.