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心房利钠肽(AP)对肾小球滤过的影响是一有争论的问题。早期研究表明,心房提取物(ANF)能增加尿钠排泄,但不伴有肾小球滤过率的改变。本文作者观察了ANF 和APII 对大鼠肾小球滤过压的作用,提出了新的看法。雄性大鼠腹腔麻醉,股动脉插管测量动脉压;并将一外径为3～5μm 测压吸管任意插入一段近端小管内,其下端用蜡块堵塞,此时测得的为肾小管滞流压(stop flow pressure,SFP)。再用伺服一零位(servo-null)
The effect of atrial natriuretic peptide (AP) on glomerular filtration is a matter of debate. Early studies have shown that atrial extract (ANF) can increase urinary sodium excretion, but not associated with changes in glomerular filtration rate. The authors observed the effects of ANF and APII on glomerular filtration pressure in rats and proposed new ideas. Male rats were intraperitoneally anesthetized and femoral artery cannulated to measure arterial pressure. An external diameter of 3 ~ 5μm piezosensitive pipette was arbitrarily inserted into a proximal proximal tubule, and its lower end was blocked with wax block. At this time, renal tubular lag was measured Stop flow pressure (SFP). Then use a servo-zero (servo-null)