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目的:评估血清白蛋白检测在预测胰腺癌高剂量少分次放疗预后的价值。方法:收集未经治疗的胰腺癌III期患者,采用螺旋断层放疗设备治疗,按照高剂量少分次放疗剂量模式,放疗前行血清白蛋白检测。通过随访获取患者生存时间,评估生存时间采用Kaplan-Meier法,生存差异的比较采用Log-rank检验,相关分析采用Spearman相关分析法。结果:97例患者中位总生存时间12个月。血清白蛋白高值组中位生存时间15个月,低值组中位生存时间9个月,生存分析显示血清白蛋白水平与总生存时间在统计学上有关(P=0.007),放疗前血清白蛋白水平与放疗前减黄(r=-0.24,P=0.018)呈负相关,与肿瘤部位(r=0.279,P=0.006)呈正相关。结论:胰腺癌高剂量少分次放疗前血清白蛋白检测在预测患者总生存时间方面具有重要价值。
Objective: To assess the value of serum albumin in predicting the prognosis of high-dose and fractionated radiotherapy for pancreatic cancer. Methods: Untreated pancreatic cancer stage III patients were collected and treated with spiral CT radiosurgical equipment. Serum albumin was detected before radiotherapy according to high dose and fractionated radiotherapy dose pattern. Survival time was assessed by follow-up. The Kaplan-Meier survival time was assessed. Log-rank test was used to compare the survival differences. Spearman correlation analysis was used to analyze the correlation. Results: The median overall survival of 97 patients was 12 months. Serum albumin high median survival time of 15 months, low median survival time of 9 months, the survival analysis showed that serum albumin levels and total survival time was statistically significant (P = 0.007), pre-radiotherapy serum The albumin level was negatively correlated with the reduction of yellowing before radiotherapy (r = -0.24, P = 0.018), and positively correlated with the tumor site (r = 0.279, P = 0.006). Conclusion: The detection of serum albumin before high-dose and fractionated radiotherapy for pancreatic cancer is of great value in predicting the overall survival of patients.