20例高血压急症患者,卧位、随机、舌下含服卡托普利(10例)25 mg(最低有效量)或硝苯啶(10例)10mg。若含服20分钟后舒张压下降幅度不足1.3 kPa,则列为无效。卡托普利(平均3.3±1.2分钟溶化)组1例无效。9例有效者中,含服20分钟后舒张压由19.2±1.1 kPa降至17.1±1.2 kPa(P<0.05),30分钟后收缩压由32.7±5.2降至27.9±3.9 kPa(P<0.025);50分钟后达到最大降压效应,舒张压和收缩压分别为15.3±1.1(P<0.001)和25.3±3.3kPa(P<0.0025);降压效果持续4±2小时,其 Twenty patients with hypertensive emergency were randomly assigned to subtotal captopril (n = 10) 25 mg (minimum effective dose) or nifedipine (n = 10). If the service 20 minutes after the drop in diastolic blood pressure less than 1.3 kPa, as invalid. Captopril (mean dissolution of 3.3 ± 1.2 minutes) was ineffective in 1 case. Nine of the nine patients were effective, the diastolic blood pressure decreased from 19.2 ± 1.1 kPa to 17.1 ± 1.2 kPa (P <0.05) after 20 minutes of oral administration, and decreased from 32.7 ± 5.2 to 27.9 ± 3.9 kPa after 30 minutes (P <0.025) (P <0.001) and 25.3 ± 3.3kPa (P <0.0025), respectively. The antihypertensive effect persisted for 4 ± 2 hours